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The trade-off is that Tesamorelins approval is narrow: it applies specifically to HIV-associated lipodystrophy, not general fat loss, and its GH-axis mechanism carries monitoring requirements around IGF-1 and glucose that AOD-9604s trials did not show

Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, et al

(2022) 12(3):e12129

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It also remains unknown whether BDNF expression in specific hippocampal subregions is more critical than in other subregions