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Gradual titration (dose escalation) leads to better tolerability

doi: 10.3389/fendo.2020.00178 [DOI] [PMC free article] [PubMed] [Google Scholar] 16.Mann JFE, Fonseca VA, Poulter NR, et al

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In this context, the antitumor activity reported for incretin-based polyagonists should not be interpreted as evidence for GCGR agonism alone, but rather as an indication that coordinated multi-receptor targeting may induce favorable systemic metabolic remodeling (62,63)