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doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

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Those with more body fat can use 90 degrees (straight in), while leaner individuals may prefer 45 degrees to ensure the injection stays in the subcutaneous layer

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