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All data were expressed as means the standard error of the mean (SEM), and differences between groups in assays were determined by one-way ANOVA followed by Tukeys post hoc multiple comparison test using GraphPad Prism 5 software

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We first interrogated the effect of dulaglutide in the absence and then in the presence of rolipram, a phosphodiesterase 4 inhibitor, on the beating rate in mouse right atrial preparations

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