Tirzepatide (Mounjaro for diabetes, Zepbound for weight loss) are also sometimes included with GLP1s, although they work a little differently
The starting dose (2.5 mg) is $299 per month and the 5 mg dose is $399
In the periphery, pre-proglucagon derived peptides, Glucagon-Like Peptide-1 (GLP-1), Glucagon-Like Peptide-2 (GLP-2) and oxyntomodulin (OXM) are involved in a wide variety of physiological functions, including glucose homeostasis, gastric emptying, intestinal growth, insulin secretion as well as the regulation of food intake
We now refer to acetylcholine as an endothelium-dependent vasodilator, and we also recognize that endothelial dysfunction, which can be defined as a reduced vasodilator response to acetylcholine, is an early prognostic indicator for the onset of cardiovascular disease (168171)
People may microdose GLP-1 medications for many reasons, including: They have hit their target weight goal They have concerns about the cost of the medications They are sensitive to the side effects of the medications They want to just suppress their appetite They are worried about the supply of the medications Microdosing GLP-1 medications can come with real risks, including: Inaccurate doses Reduced effectiveness Unpredictable outcomes Possibility of regaining weight No data on the long-term effects of microdosing Minimal oversight Large clinical trials have confirmed that the standard GLP-1 doses work well when helping people lose weight and manage Type 2 diabetes
Those are just a few and there are likely quite a few more to come
