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However, the absence of muscle cramps from official labeling does not definitively exclude the possibility of an association, as post-marketing surveillance and real-world clinical experience sometimes reveal adverse effects not detected in controlled trial settings

In other words, be prepared to put in a lot of effort to convince your provider you really do need this medication

The key differentiator: injection site reactions are visible and localized

moreover it is still unclear whether GIP has direct, insulin independent, metabolic effects on adipose tissue

Iida T, Hayashi N, Yamada T, et al

The binding between GLP1 and GLP1R on various cells can activate adenylyl cyclase and increase cAMP levels, which further stimulates protein kinase A and cAMP-regulated guanine nucleotide exchange factor 2 pathways and insulin secretion [90,91]