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Mechanistically, loss of Ssu72 inhibits PPAR-mediated adipogenesis and lipid storage by hyperphosphorylation of GSK3, resulting in suppression of WAT expansion

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Following alignment, the count of mapped reads from each sample was derived and normalized as RPKM (reads per kilobase of exon model per million mapped reads)

Common side effects include nausea, bloating, reduced appetite, or mild fatigue as the body adjusts

These results indicate modest efficacy, with realistic expectations being 0.25-0.5 kg (0.5-1 pound) per week under optimal conditions

Clin Infect Dis 2014