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The reasons SGLT2is fail to reduce the occurrence of MI to a greater degree and overall stroke remain uncertain, especially in view of their reduction in blood pressure which on the basis of prior epidemiologic studies should have predicted a reduction in stroke [10]

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Allometric scaling (multiplying rodent dose by 0.162 for human equivalence) suggests a 70kg human equivalent of approximately 4.5mg

The reaction in step a) is carried out in a solvent optionally in presence of a base and/or a coupling agent which are selected from those defined above