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Treatment with higher doses of 11.25 mg/kg/day phentermine and 75 mg/kg/day topiramate (approximately 5 and 6 times maximum clinical doses based on AUC, respectively) caused reduced maternal body weight gain and offspring toxicity

Oral bioavailability studies in rats show systemic effects even when administered per os, suggesting meaningful absorption through the GI mucosa

Place band around thighs (just above knees) to engage outer thighs, or loop a longer band under feet and over shoulders

Gastrointestinal complications (gastroparesis): GLP-1 medications slow digestion by delaying stomach emptying

4, 5 PRC2 inactivation may occur at some point during progression to higher grade malignant peripheral nerve sheath tumor, which is in accordance with the observation that in our study H3K27me3 expression was lost significantly more frequently in high-grade than in low/intermediate-grade tumors