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Data availability The publicly available datasets used in this study can be accessed at cBioPortal for Cancer Genomics: CAB39, ADA and 10 other genes in Acute Myeloid Leukemia (TCGA, NEJM 2013)

Gastroparesis Profound slowing of gastric emptying could potentially lead to severe gastroparesis, particularly at high doses or in susceptible individuals

In several randomized controlled trials, ashwagandha decreased serum cortisol levels by up to 33% in people with stress

Furthermore, a recent study has highlighted astrocyte-mediated epigenetic regulation as a key factor to affect autophagy in AD, implicating altered gene expression as a driver of disease pathology 13

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Data analysis Interview transcripts were analysed using reflexive thematic analysis to identify, analyse and report patterns within the data