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& Bassell, G

Organizations involved: pharmaceutical R&D teams (Novo Nordisk, Eli Lilly), biotech startups, academic labs, specialized formulation companies, contract research organizations (CROs) for preclinical work, and CMC/CDMO partners for scale-up

Such concerns are particularly pronounced for GLP-1R-targeted nanomedicines, as GLP-1R is endogenously expressed in multiple organs, including the pancreas, kidneys, lungs, heart, and brain [555]

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Authors' contributions The authors' responsibilities were as follows--QG and JLF conceived and researched the review

"Some people may experience mild side effects, such as headaches, digestive upset or acne-like skin changes, and there can be interactions with certain medications," says Stacy Lofton, a registered dietitian and owner of Table 12 Nutrition Consulting