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Sulfasalazine is a drug that is often combined with methotrexate and hydroxychloroquine (triple therapy)

Researchers in humans have looked into how activating three receptors might affect body composition, energy intake, and controlling hunger

87 It has been shown that adiponectin increases insulin sensitivity in the liver and skeletal muscle, which is thought to be due to its ability to increase lipid and glucose metabolism

The phase 2 trial ran for 48 weeks total, and the weight loss curve had not fully plateaued by that point, suggesting continued benefits beyond the trial period