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Importantly, no significant safety signals related to thyroid axis disruption, cardiac arrhythmias, or bone metabolism have been identified to date, supporting resmetirom's liver-selective profile (Harrison et al., 2024[29])

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In 2022, the FDA placed BPC-157 on its list of bulk drug substances that may not be used in compounding under Section 503A, though enforcement actions have varied by jurisdiction [5]