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Liraglutide (Saxenda ) new use increased during 20212022, with the increase beginning slightly before the rise in semaglutide (Ozempic ) initiation rates, peaking at a rate of four per 1000 person-years in the third quarter of 2022 and rapidly declining again thereafter, concurrent with the licensing of semaglutide injection (Wegovy )

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GLP-1 receptor agonists have been shown in animal models to increase C-cell proliferation in the thyroid, raising the theoretical risk of malignancy in humans

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