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Binding GLP-1 receptors in pancreatic beta cells, enteroendocrine L-cells, and hypothalamic neurons, while simultaneously activating GIP receptors that potentiate insulin secretion and reduce glucagon output

Regular exercise training is highly recommended to patients with chronic diseases such as DM or hypertension, because of the benefits in preventing and managing the disease and better control of the symptoms, which has an impact on the diseases outcome (53)

Firstly, we found that there were no discernible differences in the weight trends of mice between those injected with PBS or P-Mn/TI@mHSA (Supplementary Fig