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Given a reduction in both GPx3 and a likely reduction of glutathione production, as has been theorized by others in the field of konzo 13 , the role of oxidative damage and mitigation as a contributing factor of disease susceptibility or severity is only further bolstered by the findings of this study

Huang, Z., Rose, A

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Therefore, combining WS-299 with an Nrf2 inhibitor (e.g., siNrf2) synergistically enhances ROS levels, increases apoptotic cell numbers, and suppresses tumor growth in vivo