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Peptides and peptide aggregates can trigger immune responses, but the likelihood for a specific preparation depends on sequence, purity, formulation, route, storage, patient factors, and repeated exposure

Typically, 5 or 6 variable amino acids are introduced, ensuring that the total number of cyclic peptide library members (3.2 10 6 and 6.4 10 7 , respectively) remains below the maximum number of E

L-carnitine naturally occurs in the body and is usually consumed by people in the form of a supplement

Acknowledgements This research was supported by National Key R&D Program of China (2021YFF0702600), the National Natural Science Foundation of China (82222056 and 82111530099), Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510), the Natural Science Foundation of Guangdong (2022A1515012316), the Guangdong International Joint Research Program (2020A0505100027), and National Key Clinical Discipline

For mitochondrial function assay, methyl thiazolyl diphenyl-tetrazolium bromide (MTT) assay was performed

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