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2 T2DM causes changes in cognitive function 2.1 Cognitive impairment in T2DM: stages and risk factors In individuals with T2DM, cognitive functioning undergoes distinct stages of impairment, ranging from diabetes-associated cognitive decrements to MCI and dementia (Koekkoek et al., 2015)

TGF-1 is an important cytokine that induces fibrosis in organs such as the kidneys and lungs [39, 40], and can activate PSCs to induce pancreatic fibrosis [41, 42]

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