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Not only did different animal models such as rats, mice, rabbits and hamsters, help in the discovery and understanding of the therapeutic pathway of GLP-1 drugs, but they also provided crucial data on drug safety, pharmacokinetics and organ-specific effects, all of which were necessary for achieving regulatory approval and the successful translation to human use

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This approach improves patient outcomes, reduces unnecessary treatment costs, and supports more sustainable coverage decisions for payors

doi: 10.1016/j.bbr.2021.113226 149 VasconcelosG

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