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Standard angiogenic factors like VEGF primarily accelerate growth without this built-in regulatory mechanism

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The MRP proteins mediate not only GSH efflux, but they also export oxidized glutathione derivatives (e.g., glutathione disulfide (GSSG), S-nitrosoglutathione (GS-NO) and glutathione-metal complexes), as well as other glutathione S-conjugates [18]

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The disruption compromises the structural integrity affecting the cells capacity for cell transport, energy production, and ion balance [87]