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An important note for GLP1 GI AEs is that standard approaches may not correctly characterise the incidence of GI AEs given the mechanism of action of GLP1 RAs, which decrease gastric emptying and suppress appetite to reduce overall food intake

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The absolute bioavailability following intramuscular injection was found to be approximately 1419% in rats and 4551% in beagle dogs, indicating variable absorption depending on the species and administration route

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