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Conclusion This review elucidated the significance of the metabolism-inflammation-oxidative stress axis in the occurrence and development of OA, and also dialectically discussed the mechanisms and clinical benefits of beneficial nutrients in the treatment of OA

The system Xc-, GPX4 and GSH (system Xc-/GSH/GPX4) pathways have been identified as crucial players in ferroptosis (28,29) (Fig

It also promotes an increase in energy levels and metabolism by utilizing stored fats as an energy source

These pathways require plenty of water to flush out the waste products the liver processes

17 CoQ10 may also help protect cells from damage caused by high blood sugar, lowering the risk of common diabetes-related complications

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