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Proof comes from animal studies, as well as preliminary human trials with inconsistent outcomes and doses

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During eating and swallowing, oral bacteria and their metabolites are carried with saliva from the mouth into the gastrointestinal tract 19

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Sharma N, Madan P, Lin S (2016) Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: a co-surfactant study