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After feeding all branching pathways, the excess of glycolytic flux is converted to lactate to preserve a sufficient pool of NAD+ for glycolysis and also to avoid the tricarboxylic acid (TCA) cycle inhibition due to excess NADH

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10.3945/an.116.013516 282 SekiT.HosonoT

Controlled detonation: evolution of necroptosis in pathogen defense

The results tend to be subtle and natural-looking rather than dramatic overnight changes

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