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Allulose has been generally recognized as safe (GRAS) by the FDA and shows a favorable safety profile in short-term studies

manufacturer-direct programs (NovoCare, LillyDirect) require an external prescriber

Brown or amber discoloration indicates oxidation and degradation

The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys

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Fungal Genet Biol 49:302312 Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW (2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxidative species, and ageing in Saccharomyces cerevisiae