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It is important to distinguish between localized injection site pruritus and generalized itching affecting broader areas of the body, as these may have different underlying mechanisms and clinical significance

While Tet2 promotes astrocyte differentiation from neural stem cells by demethylating astroglial genes, like Gfap , the transcription factor Olig2 suppresses Tet2 expression, thereby indirectly inhibiting astrocyte formation (He et al., 2020)

PubMed Narkevich, V.B., Kudrin, V.S., Klodt, P.M., Pokrovskii, A.A., Kozlovskaya, M.M., Maiskii, A.I., & Raevskii, K.S

This is when most patients commit fully to completing the 48-week course, having proof they can tolerate it and seeing meaningful results on the scale

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Avoid placing it on the refrigerator door