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The drug interaction databases classify this as a moderate interaction, noting that "as you lose weight during treatment with phentermine, your dosage requirement of tirzepatide or any other diabetic medications may change." This is not a minor technicality

More intense workouts burn more calories and build more muscle, which in turn elevates your resting metabolism

However, using a liposomal formula can often reduce these issues as it is designed for better absorption

If you notice any of these signs, do not use the medication and reach out to your compounding pharmacy immediately for guidance

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"Generic protocol for population-based surveillance of Haemophilus influenzae type B" (PDF)