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When hydroxocobalamin is given in high doses (such as during cyanide poisoning treatment), unique effects can be observed: patients often experience a transient reddening of the skin or mucous membranes and a reddish discoloration of the urine due to drug excretion
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Compound 4e with the Br substituent on the para -position exhibits the promising activity with the IC 50 values of 1.95 M
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