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First, AR expression in the human has a slight bimodel expression with elevations occurring during the newborn period and again at 16 to 20 years of age with down regulation of the AR occurring between 21-30 years of age

IL1 is upstream of IL6, with broader effects, and its inhibition increased the risk of sepsis (though it did cut cardiovascular risk)

To minimise unwanted effects, always start with a low dose and build up gradually

Role of Selenium-Dependent Glutathione Peroxidases (Seleno-GPxs) in Radio-Modulation: Lessons for Radiation Oncology

It also serves as a cautious restart or a taper floor

[PubMed Central ID: PMC7145895]