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Cerebrospinal fluid concentrations rise within approximately 30 minutes of an intranasal dose and are reported to reach roughly 60 to 70 percent of corresponding plasma concentrations in rodent studies, a striking ratio for a peptide of this size

The minimal direct evidence currently available is consistent with this and indicates that Nrf2 may be critical for protection against ferroptosis

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For transparency we still reported the mortality findings

The Emerging Role of Ferroptosis in Inflammation

Together, these studies redefine GSH as a multifaceted regulator of cellular metabolism and compartment-specific homeostasis, rather than merely a passive antioxidant reservoir