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While low B12 rarely triggers diarrhea or other gastrointestinal issues directly, theyre usually a symptom of a more complex problem like B12-deficiency anemia or Crohns disease

It's being called a " wolverine peptide ," praised by influencers for healing everything from achy joints to leaky gut, and positioned as something midlife women have been missing

For context, the fat-mass reductions reported in Billon 2024 roughly 25-30% in diet-induced obese mice over 28 days without exercise are large for a preclinical metabolic agent and explain why the "exercise mimetic" label stuck

A 2026 biopharmaceutical review in a journal I do not trust said there is no identified high-affinity receptor, no validated molecular target, and a wide disconnect between the tidy preclinical effects and any coherent pharmacology