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Clinical studies show modest weight loss of 2-5 pounds over 12 weeks, with more significant improvements in metabolic markers like fasting glucose and HbA1c

serious risks include pancreatitis, gallbladder disease, and hypoglycaemia when combined with certain diabetes medicines

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Using Kaede photoconvertible mice, experiments demonstrated that CD8+ effector T cells that enter and stay in the tumor develop an exhausted phenotype within 72 hours, whereas non-effector TCF1+ stem-like CD8+ T cells are continuously trafficked between the tumor and the TDLNs (47)

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