Last reviewed: July 6, 2026 Last updated: July 6, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
GLP-1 RA therapy reduces the risk of incident atrial fibrillation by 46% in patients with HFpEF and HFmrEF while also improving weight, blood pressure, and left atrial remodeling
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Moreover, treatment with GP in mice with DSS-induced colitis resulted in the suppression of pro-inflammatory cytokines TNF-, IL-6, IL-1, IL-17A, and IFN-, modulation of intestinal barrier-related factors occludin-1 and ZO-1, enhancement of intestinal flora diversity, and an increase in Lactobacillus population [231]
Aberrant immune responses promote vascular inflammation, leading to endothelial dysfunction, vascular remodeling, and increased peripheral vascular resistance, which eventually drive blood pressure elevation (235, 236)
They are designed to complement weight loss medication as part of a balanced diet and should not replace advice from your prescribing GP, endocrinologist, or Accredited Practising Dietitian
