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Methane-dominant SIBO tends to cause constipation and responds to different antimicrobials than hydrogen-dominant SIBO, which more commonly causes diarrhea

KPV suppresses excessive inflammatory signaling, modulates cytokine activity, and supports immune equilibrium without dampening host defense

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Gastrin is a neuroendocrine peptide, which acts on the cholecystokinin-2 (CCK2) receptor and is expressed in the pancreas with the rationale being that as it is involved in pancreas development, it might increase -cell mass and glycemic control [70]