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The other thing to keep in mind is...you know, because one of the questions a friend of mine asked me recently, actually a mutual friend, Tim Ferris, is "Can we take too much leucine during a workout?" And again, I don't think we know the answer but extrapolating from the animal data I think 5 grams of leucine during a workout, probably not harmful

10.1038/s41598-020-67532-2 54 ZengM.SunR.BasuS.MaY.GeS.YinT.et al (2016)

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5c), consistent with our observation that LaccID lacks activity in these compartments