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It is worth noting that patients with mUPD are more likely to have GHD compared to those with deletions (80% versus 25%) (100, 107109)

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Their signs may include difficulty breathing, swelling of the face or neck, severe pain, vomiting, fever, and yellowing of the skin or eyes [25]

45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization

Later, these effects were replicated with a brain infusion of exendin-4, the agonist of the GLP-1 receptor [69, 100]