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Since 2005, a number of them have been approved by the FDA to treat type-2 diabetes, one of the comorbid conditions Warner referred to, such as exenatide, or Byetta

The physiological role of glucagon-like peptide-1 in the regulation of renal function

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this difference may result from a ~5x stronger effect produced by GLP-1 analogs, compared to DPP-4 inhibitors (Charbonnel & Cariou, 2011) No change in weight Contraindications: type I diabetes (these patients lack pancreatic beta cells) diabetic ketoacidosis (it would not be effective for treating this condition) an association between DPP-4 inhibitors and heart failure has been observed for two members of this drug class in patients with type 2 DM and atherosclerosis