Unforeseen Reactions In February 2025, the paper, Euglycemic Ketoacidosis Following Coadministration of an SGLT2 Inhibitor and Tirzepatide , appeared in JCEM Case Reports , describing a patient who was admitted to the intensive care unit after being placed on both medications
Overall, the selected trials had a low to moderate risk of bias
Rocio Pereira, MD, chief of Endocrinology at the safety-net hospital system Denver Health and an associate professor of medicine at the University of Colorado, says that many of her patients report that semaglutide helps them eat less and that it has become easier for them to eat healthy foods and avoid junk food since starting on the medication
They enhance glucose-dependent insulin secretion, suppress glucagon release, and slow gastric emptying, while supporting the preservation of pancreatic beta-cell function
GLP-1 receptor agonists are widely expressed in the brain, playing a role in reward and addiction pathways
These changes occur quickly so its not a long-time horizon to realize these benefits (from a sheer cost perspective). Obesity: A Dynamic Endocrine Issue In June 2013, the American Medical Association acknowledged obesity as a disease, writing in its resolution, The suggestion that obesity is not a disease but rather a consequence of a chosen lifestyle exemplified by overeating and/or inactivity is equivalent to suggesting that lung cancer is not a disease because it was brought about by individual choice to smoke cigarettes. Ten years later, and theres much more work to do
