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Stress, health problems, bad sleep, or other things might cause this extreme tiredness

Opioid-induced esophageal dysfunction (OIED): Cases of OIED have been reported in patients taking opioids and may occur more frequently in patients taking higher doses of opioids, and/or in patients taking opioids longer term (see WARNINGS)

He says that the answer is a resounding yes

Assessment of cardiovascular autonomic function

Oxidative stress is when you dont have sufficient antioxidants in the body so that free radicals start damaging our genetic material as well as our organs