Symptoms may include frequent urination, constipation, and severe abdominal pain or pressure
It is a synthetic peptide made from a sequence related to a protective protein found in gastric juice
Issues raised in academic and consumer reviews include irritation in cosmetic-formulation use, very wide variation in product quality across the unregulated marketplace, formulation-stability problems, ingredient-interaction concerns, and a thin clinical-trial evidence base relative to the strength of consumer marketing claims
PMID:30342710
It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria
Li X, Li W, Wang M, Liao Z