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REDEFINE 1: Strong Results, Missed Ambitions The first pivotal trial, REDEFINE 1, enrolled 3,417 adults with obesity or overweight and at least one weight-related comorbidity, but without type 2 diabetes

He et al., 2017

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However, a potential limitation of the work is that other alternative sources of amino acids, including cysteine, may exist in the tumour interstitial fluid, and their relative contribution has not yet been defined