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None of them have gone through what would be considered adequate clinical trials, but nonetheless many people are taking these

INDICATIONS AND USAGE Cyanocobalamin is indicated for vitamin B 12 deficiencies due to malabsorption, which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency Cyanocobalamin Injection, USP is also suitable for the vitamin B 12 absorption test (Schilling test)

First, the pathological mechanisms of these two diseases are markedly different

T ransient nausea, diarrhea, and mild irritation at the injection site have been reported as adverse undesirable effects in preclinical studies

The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer

Trachy RE, Fors TD, Pickart L, Uno H