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Drug interactions are most clinically important with insulin and sulfonylureas (hypoglycaemia risk), DPP-4 inhibitors (dont combine), and (for Mounjaro only) oral contraceptives and oral HRT

They include: Vegans and vegetarians: Most B12 is found in animal products

Advise observing for negative responses and modifying methods accordingly

[DOI] [Google Scholar] 5.Sies H

It improves vessel wall stability and decreases inflammatory infiltration, providing a protective role in heart and vascular injury models

190 This tissue-specific shift from transcriptional repression to coactivation reflects the flexible integration of local metabolic signals through SHP