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Animal studies spanning over 20 years show gastric ulcer healing, tendon repair, muscle regeneration, and neuroprotection with minimal toxicity, even at doses 10 to 100 times the therapeutic range (Sikiric et al., Curr Pharm Des 2018)

Nevertheless, in the context of pathological stimuli such as hypoxia, microbial infection, or tumorigenesis, the levels of exRNA demonstrate a dosedependent increase, attaining concentrations 10to 100fold higher than the baseline [126]

Cell Tissue Res 377, 153159 (2019)