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Or will high costs, insurance restrictions, side effect burdens, and supply constraints limit them to a small fraction of eligible patients

This may be the result of disturbed function of the ThDP-dependent 2-oxoglutarate dehydrogenase (Figure 1), as a universal effect of its inhibition is perturbation in relative amino acid abundance and a subsequent decrease in protein synthesis (196, 197)

More evidence is needed to understand long-term effects that remain unknown

TABLE 1 Pharmacological effects of catalpol in kidney diseases