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Some limited evidence suggests that GLP-1 receptor agonistsa drug class related to tirzepatide's mechanism of actionmay have indirect effects on erectile function through improvements in weight, glycaemic control, and cardiovascular risk factors

The 2025 American College of Rheumatology guidelines for SLE treatment and the 2025 EULAR recommendations for lupus nephritis both acknowledge the potential role of metabolic therapies including GLP-1 medications