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New Insights into the Role of Glutathione in the Mechanism of Fever

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(2013) 4:e33

If you miss it, there can be dire consequences

Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)