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However, when the brain is in a state of high metabolic demand, such as during learning or memory processing, pyruvate is instead reduced to lactate by lactate dehydrogenase A (LDHA) using hydrogen supplied by NADH

In preclinical models, GLP-1 receptor agonists appear to modulate inflammatory signalling pathways such as nuclear factor kappa B (NF-B), a key transcription factor regulating inflammatory gene expression

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"Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer." Nature Reviews Drug Discovery, 6(10), 821-833