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This oxidative milieu persists even after glucose normalization, contributing to the phenomenon of metabolic memory observed in clinical trials, where early intensive glycemic control provides long-term protection against complications (Yang et al., 2024)

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These observations show that individual GST genes/enzymes may suppress plant resistance in the initial biotrophic phase of the infection, possibly by providing a high antioxidative capacity favorable to the fungus (Hernndez et al., 2009)

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anti-inflammatory and vasodilatory properties versus involvement in mucus secretion)

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Future research should explore precision combination strategies based on biomarkers, such as NFE2L2, to optimize treatment for relapsed/refractory HL (103)

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Baseline assessment may be individualized based on clinical judgment

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