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Hepatic Impairment: Chronic alcoholic liver disease and probably other diseases with decreased or abnormal plasma proteins (albumin) reduce the total plasma concentration of naproxen, but the plasma concentration of unbound naproxen is increased

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Eur J Endocrinol 181(3):R211R234

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"In this study, we have deliberately refrained from introducing index ranges for mild, moderate, and severe enlargement, because the grading would be arbitrary and was not included in the study design." Thus, what would be "arbitrary" to the authors of the 2002 study (and therefore should be excluded) now, in the EPIC Study report, is "top tier" (as one of its authors has described it)